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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TOP2A All Species: 13.94
Human Site: S1302 Identified Species: 21.9
UniProt: P11388 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P11388 NP_001058.2 1531 174385 S1302 S D S E S D R S S D E S N F D
Chimpanzee Pan troglodytes XP_516332 1634 184611 K1349 P W S D D E S K S E S D L E E
Rhesus Macaque Macaca mulatta XP_001092092 1620 182490 K1335 P W S D D E S K S E S D L E E
Dog Lupus familis XP_537646 1532 174610 S1303 D S E S D M S S N E S N F D V
Cat Felis silvestris
Mouse Mus musculus Q01320 1528 172859 S1298 S D S E S D V S S N E S N V D
Rat Rattus norvegicus P41516 1526 173202 S1298 S D S E S D M S S N E S N F D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001519680 1746 195650 S1332 S D S E S D L S C D D S D I D
Chicken Gallus gallus O42130 1553 174974 A1324 R V V R Q A A A K I K P M V N
Frog Xenopus laevis NP_001082502 1579 178601 L1317 S E S D V E E L V P R I A Q P
Zebra Danio Brachydanio rerio NP_001003834 1574 177254 D1311 D E G E S D S D L E L M S E E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P15348 1447 164377 A1218 V K S M G G G A G A G D V F P
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q23670 1520 172316 Y1287 D A A T K A K Y E K M S Q P K
Sea Urchin Strong. purpuratus XP_783546 1448 163750 V1219 E S S G L T G V S S K M T K G
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P30182 1473 164089 N1236 S A M D T D N N V A E V V K P
Baker's Yeast Sacchar. cerevisiae P06786 1428 164196 E1200 K R K L V D D E D Y D P S K K
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 67.2 67.5 93.6 N.A. 89 88.7 N.A. 71.3 76.3 70.7 67.9 N.A. 51.2 N.A. 53 58.9
Protein Similarity: 100 78.6 78.4 96.4 N.A. 93.6 93.2 N.A. 79.1 85 81.8 78.8 N.A. 66.8 N.A. 70.4 73.4
P-Site Identity: 100 13.3 13.3 6.6 N.A. 80 86.6 N.A. 66.6 0 13.3 20 N.A. 13.3 N.A. 6.6 13.3
P-Site Similarity: 100 40 40 26.6 N.A. 86.6 93.3 N.A. 80 20 33.3 46.6 N.A. 20 N.A. 20 20
Percent
Protein Identity: N.A. N.A. N.A. 45 42.2 N.A.
Protein Similarity: N.A. N.A. N.A. 61.4 60.4 N.A.
P-Site Identity: N.A. N.A. N.A. 20 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 40 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 14 7 0 0 14 7 14 0 14 0 0 7 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 7 0 0 0 0 0 0 % C
% Asp: 20 27 0 27 20 47 7 7 7 14 14 20 7 7 27 % D
% Glu: 7 14 7 34 0 20 7 7 7 27 27 0 0 20 20 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 7 20 0 % F
% Gly: 0 0 7 7 7 7 14 0 7 0 7 0 0 0 7 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 7 0 7 0 7 0 % I
% Lys: 7 7 7 0 7 0 7 14 7 7 14 0 0 20 14 % K
% Leu: 0 0 0 7 7 0 7 7 7 0 7 0 14 0 0 % L
% Met: 0 0 7 7 0 7 7 0 0 0 7 14 7 0 0 % M
% Asn: 0 0 0 0 0 0 7 7 7 14 0 7 20 0 7 % N
% Pro: 14 0 0 0 0 0 0 0 0 7 0 14 0 7 20 % P
% Gln: 0 0 0 0 7 0 0 0 0 0 0 0 7 7 0 % Q
% Arg: 7 7 0 7 0 0 7 0 0 0 7 0 0 0 0 % R
% Ser: 40 14 60 7 34 0 27 34 40 7 20 34 14 0 0 % S
% Thr: 0 0 0 7 7 7 0 0 0 0 0 0 7 0 0 % T
% Val: 7 7 7 0 14 0 7 7 14 0 0 7 14 14 7 % V
% Trp: 0 14 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 7 0 7 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _